KMID : 1141520200350040960
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Endocrinology and Metabolism 2020 Volume.35 No. 4 p.960 ~ p.964
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Establishment of Reference Intervals for Serum Insulin-Like Growth Factor I in Korean Adult Population
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Kim Bo-Yeon
Cho Yong-Geun Ku Cheol-Ryong Lee Sang-Guk Lee Kyung-A Kim Jeong-Ho
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Abstract
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Appropriate reference intervals of serum insulin-like growth factor I (IGF-I) is important for diagnosing and monitoring patients with growth hormone-related diseases. To establish reference intervals, adult individuals (n=1,334, 680 men and 654 women) were divided into six age groups (20-29, 30-39, 40-49, 50-59, 60-69, ¡Ã70). Serum IGF-I was measured by chemiluminescence immunoassay (Liaison). Concordance of patient classification based on reference intervals, manufacturer¡¯s intervals, and standard deviation score (SDS) was evaluated. New reference intervals had higher upper and lower limits than those specified by the manufacturer. The agreement between classification using new reference interval and the manufacturer¡¯s reference interval, and that using new reference interval and SDS was 75.0% (weighted kappa, 0.17), 91.9% (weighted kappa, 0.51) in men and 91.0% (weighted kappa, 0.41), 92.5% (weighted kappa, 0.53) in women, respectively. Reference intervals should be established not only based on age and sex, but also on ethnicity and assay method.
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KEYWORD
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Insulin-like growth factor I, Reference values, Luminescent measurements
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